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Condition guide · /premature-ejaculation/
Premature ejaculation treatment
Reviewed by Dr. Arjun Mehta, PharmD — Head Pharmacist. Updated May 2025.
1 in 3
Men affected
<1 min
Defined PE
85%
Improve on Rx
3
FDA-related options
ED medicines in this guide
From $30
From $32
From $38
From $92
From $41
About this condition
Premature ejaculation (PE) is the most common sexual problem in men, affecting up to one in three at some point in life. It is defined clinically as ejaculation that consistently occurs within about one minute of penetration and that causes distress for the person or their partner.
PE often has a psychological component (anxiety, performance pressure, relationship stress) but it can also be driven by biology — particularly variations in serotonin signalling. Both are treatable, often together: medication slows ejaculation, while behavioural techniques and counselling address the psychological side.
Treatment options
Sertraline (off-label)
Daily SSRI used off-label for PE. Slower onset but well-studied. From $18.
Dapoxetine
Daily SSRI used off-label for PE. Slower onset but well-studied. From $18.
Lidocaine spray/cream
Topical anaesthetic applied 10–15 minutes before sex. Reduces sensation, delays ejaculation.
Behavioural therapy
Stop-start and squeeze techniques. Often combined with medication for best results.
Common questions
Is PE treatable?
Do I need a prescription?
Yes. Dapoxetine, sertraline and other SSRIs are prescription-only. We dispense against a valid prescription verified by our pharmacist.
Can I combine PE and ED treatment?
Some men have both PE and ED. Combination therapy (a PDE5 inhibitor with dapoxetine) is well-studied. Your prescriber will advise on what is suitable for you.
Dr. Arjun Mehta, PharmD · Head Pharmacist
/our-pharmacists/arjun-mehta/ — Reviewed May 2025
This guide is reviewed every 12 months or sooner when clinical guidance changes. If you have a specific medical question, call our pharmacist team — we answer the phone, not a bot.
