Vardenafil

What Are Vardenafil?

Vardenafil is a highly selective PDE5 inhibitor and the active ingredient in Levitra — the second PDE5 inhibitor approved by the FDA after Sildenafil. Vardenafil is approximately 10x more potent than Sildenafil at the PDE5 enzyme, allowing effective ED treatment at lower doses. It is particularly favoured by men with diabetes-related ED and those who experience visual side effects with Sildenafil (due to Vardenafil’s higher PDE5 selectivity over PDE6). AmozonPill stocks 22 generic Vardenafil products across standard tablets and oral dissolving strips — sourced from FDA-inspected, WHO-GMP manufacturers at up to 95% below Levitra’s brand price. 

 Drug Classes Available

• Vardenafil Standard Tablets: 10 mg, 20 mg — standard on-demand doses. Taken 25–60 minutes before sexual activity. Duration 4–5 hours. Slightly faster onset than Sildenafil; mildly less affected by food. 40 mg, 60 mg high-dose options available for refractory cases under physician guidance. 
• Vardenafil Oral Dissolving Strips / Sublingual: Vardenafil ODT (orodispersible) — dissolves on or under the tongue, absorbed via buccal mucosa. Faster onset than conventional tablets (15–30 minutes); no water required. Staxyn equivalent. Brand: Zhewitra Oral Jelly, Vilitra ODT. 
• Vardenafil + Dapoxetine: Snovitra Super Power — Vardenafil 20 mg + Dapoxetine 60 mg for combined ED and premature ejaculation treatment. 

 Why Buy Generic? 

• Generic Vardenafil 20 mg from $2.50/pill vs $18+ per Levitra pill 
• Same active ingredient as Levitra — same PDE5 inhibition mechanism 
• Multiple brands: Vilitra, Zhewitra, Snovitra 
• FDA-inspected, WHO-GMP Indian manufacturers 
• Free shipping on orders over $199 

How to Choose the Right Product

For most men: start with Vardenafil 10 mg, 25–60 minutes before sexual activity. If insufficient: increase to 20 mg. Vardenafil is a particularly good choice for men with diabetes-related ED (higher response rate than Sildenafil in this group), men who experience visual side effects with Sildenafil (due to lower PDE6 inhibition), and men who want slightly faster onset than standard Sildenafil tablets. For fastest onset without water: choose the oral dissolving strip (ODT) formulation. Vardenafil is contraindicated with nitrates — as with all PDE5 inhibitors. 

Frequently Asked Questions

What makes Vardenafil different from Sildenafil? 

Vardenafil is approximately 10x more potent at PDE5, meaning it works at lower doses. It also has higher selectivity over PDE6 (the enzyme responsible for Sildenafil’s visual side effects — blue tinge, light sensitivity), resulting in fewer visual disturbances. Vardenafil’s onset is slightly faster than Sildenafil and it is less affected by food. 

Does Vardenafil work for diabetic ED? 

Yes — and notably, Vardenafil has stronger clinical trial evidence in diabetic ED than some other PDE5 inhibitors. Diabetes damages both penile blood vessels and nerves, making ED harder to treat. Multiple studies show Vardenafil achieves successful intercourse in 72% of diabetic men with ED, including those with severe neuropathy. 

What is an oral dissolving strip (ODT) Vardenafil? 

Vardenafil ODT (orodispersible tablets or strips) dissolve on or under the tongue, bypassing first-pass metabolism for faster and more predictable absorption. Onset occurs in 15–30 minutes vs 30–60 minutes for conventional tablets. They are discreet, require no water, and are popular for spontaneous use. 

How does Vardenafil compare to Tadalafil? 

Vardenafil and Tadalafil are both effective PDE5 inhibitors. Tadalafil has a significantly longer duration (36 hours vs 4–5 hours) and is available as a once-daily formulation. Vardenafil has slightly faster onset and may be preferred by men with diabetes or those sensitive to Sildenafil’s visual side effects. Choice is largely based on personal preference and duration required. 

Can Vardenafil be taken with blood pressure medication? 

Vardenafil causes modest blood pressure lowering on its own. When combined with alpha-blockers (Tamsulosin, Doxazosin), it can cause symptomatic hypotension — allow at least 6 hours between Tamsulosin and Vardenafil. It is absolutely contraindicated with nitrates. Always inform your physician about all current medications before starting Vardenafil. 

What is the maximum dose of Vardenafil? 

The maximum recommended dose of standard Vardenafil tablets is 20 mg per 24 hours. For the ODT formulation: maximum 10 mg per 24 hours. Higher doses (40–60 mg) are available in generic products but should only be used under physician supervision. Elderly patients and those with liver impairment should start at 5 mg.