Reviewed by Dr. Arjun Mehta, PharmD — Head Pharmacist. Updated May 2025.
First-line GERD
Healing course
Cause of most ulcers
Digestive complaints — acid reflux, indigestion, peptic ulcers, irritable bowel — are some of the commonest reasons people see a doctor. Most respond very well to medication once the cause is identified.
Acid-related disease (GERD, ulcers) is treated primarily with proton-pump inhibitors (PPIs) like pantoprazole or esomeprazole, which strongly reduce stomach-acid production. Peptic ulcers caused by H. pylori infection also need a course of antibiotics (triple therapy). For IBS and functional dyspepsia, treatment is more individualised.
Pantoprazole, esomeprazole, rabeprazole. First-line for reflux and ulcers. Once daily before breakfast.
Famotidine. Useful for breakthrough symptoms on top of a PPI, or in patients who don’t tolerate PPIs.
Triple therapy: PPI + amoxicillin + clarithromycin for 7–14 days. Cure rates above 80%.
Hyoscine, mebeverine. Used for cramp-type IBS pain. Symptom relief rather than cure.
Most people use a PPI for 4–8 weeks for healing, then step down. Long-term use is reasonable for severe reflux or Barrett’s oesophagus, but should be reviewed yearly.
Yes if you have a peptic ulcer or persistent dyspepsia. A simple breath or stool test confirms infection
Generally safe, but very long-term use is associated with slightly lower B12 and magnesium and small increases in some risks. Use the lowest effective dose.
/our-pharmacists/arjun-mehta/ — Reviewed May 2025
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