Home › Sexual health › Libido and testosterone treatment
Reviewed by Dr. Arjun Mehta, PharmD — Head Pharmacist. Updated May 2025.
Men 40+ low T
Treatment forms
Time to full effect
Always required
Low libido and low testosterone (hypogonadism) are two related but distinct issues. Libido is the desire for sex; testosterone is the hormone that helps drive it. Low testosterone reliably reduces libido, but libido can also be lowered by stress, depression, medication side effects, relationship factors or sleep deprivation — even when testosterone is normal.
Treatment depends on the cause. Confirmed low testosterone in a symptomatic man can be treated with testosterone replacement therapy (TRT). Libido issues without low T are usually treated by addressing the underlying cause (sleep, mental health, medication review) rather than with hormones.
Cypionate or enanthate, given every 1–2 weeks. The most studied form of TRT.
Daily topical application. Convenient but requires care to avoid transfer to partners or children.
Stimulates the body’s own testosterone production. Preserves fertility, useful in younger men.
Weight loss, strength training, sleep and stress reduction can meaningfully raise natural testosterone.
Two morning total testosterone blood tests, alongside symptoms (low libido, fatigue, mood). A diagnosis is not made on symptoms alone.
TRT is safe when prescribed and monitored properly, with regular blood tests. It is not appropriate for everyone — men with prostate cancer, severe sleep apnoea or fertility plans need careful evaluation.
Yes — it suppresses sperm production. Men wishing to preserve fertility may be offered clomiphene or hCG instead.

/our-pharmacists/arjun-mehta/ — Reviewed May 2025
This guide is reviewed every 12 months or sooner when clinical guidance changes. If you have a specific medical question, call our pharmacist team — we answer the phone, not a bot.
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